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ranitidine

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Origin: China

Cas No: 66357-35-5

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
66357-35-5
Other Names:
Ranitidine Hydrochloride
MF:
C13H23ClN4O3S
EINECS No.:
266-332-5
Place of Origin:
Shaanxi, China
Type:
Antibiotic and Antimicrobial Agents
Grade Standard:
Medicine Grade
Usage:
Animal Pharmaceuticals
Brand Name:
WUCINE
Model Number:
WUCINE-1727
Purity:
99%
Product Name:
Ranitidine HCL
Appearance:
White Powder
Assay:
HPLC 99%
Molecular Weight:
314.4038
Melting point:
69-70℃
Boiling point:
437.1°C at 760 mmHg
Flash point:
218.2°C
Shelf life:
2 years
Storage:
Cool Dry Place
Package:
Aluminum Foil Bag
Packaging&Delivery
Packaging Details
1kg per bag with double plastic inside and aluminium foil bag out side
25kg/Fibre drum with double plastic bag inside
or according to customers' require
Port
Any port of China
Lead Time:
Quantity(Kilograms) 1 - 100 >100
Est. Time(days) 3 To be negotiated

Property

CAS No.: 66357-35-5 Formula: C13H22N4O3S Molecular Weight: 314.40400

Description

Ranitidine, sold under the trade name Zantac among others, is a medication that decreases stomach acid production. It is commonly used in treatment of peptic ulcer disease, gastroesophageal reflux disease, and Zollinger–Ellison syndrome. There is also tentative evidence of benefit for hives. It can be taken by mouth, by injection into a muscle, or into a vein.
Common side effects include headaches and pain or burning if given by injection. Serious side effects may include liver problems, a slow heart rate, pneumonia, and the potential of masking stomach cancer. It is also linked to an increased risk of Clostridium difficile colitis. It is generally safe in pregnancy. Ranitidine is an H2 histamine receptor antagonist that works by blocking histamine and thus decreasing the amount of acid released by cells of the stomach.
Ranitidine was discovered in 1976 at Glaxo Pharmaceuticals, now a part of GlaxoSmithKline. It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system. It is available as a generic medication. The wholesale price in the developing world is about 0.01 to 0.05 USD per pill. In the United States it is about 0.05 USD per dose.

Basic Info

Chemical Name	ranitidine
Synonyms	Terposen; RANITIDINE USP; Taural; Zantic; U1tidine; Sostril; Zantae; Ranitidine; Trigger; U1cex;
CAS No.	66357-35-5
Molecular Formula	C13H22N4O3S
Molecular Weight	314.40400
PSA	111.56000
LogP	2.76400

Properties

Density	1.184 g/cm3
Boiling Point	437.1ºC at 760 mmHg
Melting Point	69-70°C
Refractive Index	1.558

Safety Info

HS Code	2932999099
WGK Germany	2

Synthesis Route

Ranitidine Impurity B+carbon atom→ranitidine
N-methyl-N'-(2-[(5-dimethylaminomethyl)-furan-2-ylmethylthio]-ethyl)-urea→ranitidine
nitromethane+N-methyl-N'-(2-<(5-dimethylaminomethyl)-furan-2-ylmethylthio>-ethyl)-carbodiimide→ranitidine

Precursor

Ranitidine Impurity B
carbon atom
1,1-Bis(methylthio)-2-nitroethylene
N-methyl-N'-(2-[(5-dimethylaminomethyl)-furan-2-ylmethylthio]-ethyl)-urea

Downstream Product

ranitidine hydrochloride
N-methyl-6-nitroso-3,4-dihydro-2H-1,4-thiazin-5-amine,hydrochloride
N,N-dimethyl-5-(2(1-methylamino-2-(5-dimethylaminomethyl-2-furfuryl)-2-nitrovinylamino)ethyl-thiomethyl)furfurylamine
(6Z)-6-[[5-[(dimethylamino)methyl]furan-2-yl]methoxyimino]-N-methyl-2,3-dihydro-1,4-thiazin-5-amine

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