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alosetron

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Origin: China

Cas No: 122852-42-0

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 122852-42-0 Formula: C17H18N4O Molecular Weight: 294.35100

    Description

    Alosetron (original brand name: Lotronex LOW-trah-nex; originator: GSK) is a 5-HT3 antagonist used for the management of severe diarrhea-predominant irritable bowel syndrome (IBS) in women only. It is currently marketed by Prometheus Laboratories Inc. (San Diego). Alosetron was withdrawn from the market in 2000 owing to the occurrence of serious life-threatening gastrointestinal adverse effects, but was reintroduced in 2002 with availability and use restricted.

    Basic Info

    Chemical Name alosetron
    Synonyms

    Alosetron HCl;
    5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-3,4-dihydropyrido[4,3-b]indol-1-one;
    UNII-13Z9HTH115;

    CAS No. 122852-42-0
    Molecular Formula C17H18N4O
    Molecular Weight 294.35100
    PSA 53.92000
    LogP 2.34620

    Properties

    Appearance & Physical State crystalline powder
    Density 1.34 g/cm3
    Boiling Point 648.1ºC at 760 mmHg
    Flash Point 345.8ºC
    Refractive Index 1.706
    Vapor Pressure 1.1E-16mmHg at 25°C

    Safety Info

    Safety Statements S26-S36
    Risk Statements R36/37/38
    Hazard Codes Xi

    Synthesis Route

    4-(chloromethyl)-5-methyl-1-tritylimidazole+2,3,4,5-Tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one→alosetron
    4-Methyl-5-imidazolemethanol hydrochloride+2,3,4,5-Tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one→alosetron
    N3-BOC-5-(hydroxymethyl)-4-methylimidazole+2,3,4,5-Tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one→alosetron

    Precursor

    4-(chloromethyl)-5-methyl-1-tritylimidazole
    N3-BOC-5-(hydroxymethyl)-4-methylimidazole
    Sodium bicarbonate
    2,3,4,5-Tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one

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