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Ranitidine Impurity B

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Origin: China

Cas No: 66356-53-4

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 66356-53-4 Formula: C10H18N2OS Molecular Weight: 214.32800

    Description

    2-[[5-(Dimethylaminomethyl)-2-furanyl]methylthio]ethylamine is an impurity of Ranitidine.

    Basic Info

    Chemical Name Ranitidine Impurity B
    Synonyms

    2-[[5-[(dimethylamino)methyl]furan-2-yl]methylsulfanyl]ethanamine;

    CAS No. 66356-53-4
    Molecular Formula C10H18N2OS
    Molecular Weight 214.32800
    PSA 67.70000
    LogP 2.23340

    Properties

    Appearance & Physical State Light yellow or brown liquid
    Density 1.094 g/cm3
    Boiling Point 292.9ºC at 760 mmHg
    Melting Point 96-97 °C(lit.)
    Flash Point 130.9ºC
    Refractive Index 1.547

    Safety Info

    Safety Statements S26; S36/37/39; S45
    HS Code 2932190090
    RIDADR UN 2735
    Risk Statements R34
    Hazard Codes C

    Synthesis Route

    [5-[(dimethylamino)methyl]furan-2-yl]methanol+Cysteamine hydrochloride→Ranitidine Impurity B
    2-Chloroethylamine hydrochloride+2-(N,N-dimethylaminomethyl)furyl-5-(methylthiosulfonic) acid→Ranitidine Impurity B
    5-[[(2-acetamidoethyl)thio]methyl]-N,N-dimethyl-2-furanmethanamine→Ranitidine Impurity B

    Precursor

    5-[[(2-acetamidoethyl)thio]methyl]-N,N-dimethyl-2-furanmethanamine
    2-Chloroethylamine hydrochloride
    2-(N,N-dimethylaminomethyl)furyl-5-(methylthiosulfonic) acid
    [5-[(dimethylamino)methyl]furan-2-yl]methanol

    Downstream Product

    3-N-[2-[[5-[(dimethylamino)methyl]furan-2-yl]methylsulfanyl]ethyl]-1-N-methyl-4,6-dinitrobenzene-1,3-diamine
    1-N-[2-[[5-[(dimethylamino)methyl]furan-2-yl]methylsulfanyl]ethyl]-4,6-dinitro-3-N-(pyridin-3-ylmethyl)benzene-1,3-diamine
    N-[2-[[5-[(dimethylamino)methyl]furan-2-yl]methylsulfanyl]ethyl]-4-fluoro-2-nitroaniline
    N-[2-[[5-[(dimethylamino)methyl]furan-2-yl]methylsulfanyl]ethyl]-5-hydrazinyl-2,4-dinitroaniline

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