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Home > All categories> Biochemicals and Pharmaceutical Chemicals> Active Pharmaceutical Ingredients (APIs)> Genitourinary system> raloxifene
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raloxifene

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Origin: China

Cas No: 84449-90-1

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 84449-90-1 Formula: C28H27NO4S Molecular Weight: 473.58300

    Description

    Raloxifene (marketed as Evista by Eli Lilly and Company) is an oral selective estrogen receptor modulator (SERM) that has estrogenic actions on bone and anti-estrogenic actions on the uterus and breast. It is used in the prevention of osteoporosis in postmenopausal women and to reduce the risk of invasive breast cancer in postmenopausal women with osteoporosis and in postmenopausal women at high risk for invasive breast cancer.

    Basic Info

    Chemical Name raloxifene
    Synonyms

    [2-(4-Hydroxyphenyl)-6-hydroxybenzo[b]thien-3-yl] [4-[2-(1-piperidinyl)ethoxy]phenyl]methanone;
    Raloxifeno;
    6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-piperidino-ethoxy)benzoyl]benzo[b]thiophene;
    UNII-YX9162EO3I;
    Raloxifenum [Latin];
    Raloxifene [INN:BAN];
    [6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanone;
    Raloxifeno [Spanish];
    Keoxifene;
    [3H]-Raloxifene;
    Raloxifenum;
    [14C]-Raloxifene;

    CAS No. 84449-90-1
    Molecular Formula C28H27NO4S
    Molecular Weight 473.58300
    PSA 98.24000
    LogP 6.01310

    Properties

    Appearance & Physical State Light-Yellow Solid
    Density 1.289 g/cm3
    Boiling Point 728.2ºC at 760 mmHg
    Melting Point 250-253ºC
    Flash Point 394.2ºC
    Storage Condition Store in original container in a cool dark place.

    Safety Info

    WGK Germany 3

    Synthesis Route

    raloxifene hydrochloride→raloxifene
    1-(2-(4-[6-Hydroxy-2-(4-hydroxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenoxy)-ethyl)-piperidinium bromide→raloxifene
    [6-[(methylsulfonyl)oxy]-2-[4-[(methylsulfonyl)oxy]phenyl]benzo[b]thien-3-yl][4-[2-(1-pyrrolidinyl)ethoxy]phenyl]methanone hydrochloride→raloxifene

    Precursor

    1-(2-(4-[6-Hydroxy-2-(4-hydroxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenoxy)-ethyl)-piperidinium bromide
    2-(piperidin-1-yl)ethanol
    [6-[(methylsulfonyl)oxy]-2-[4-[(methylsulfonyl)oxy]phenyl]benzo[b]thien-3-yl][4-[2-(1-pyrrolidinyl)ethoxy]phenyl]methanone hydrochloride
    raloxifene hydrochloride

    Downstream Product

    1-(2-(4-[6-Hydroxy-2-(4-hydroxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenoxy)-ethyl)-piperidinium bromide
    methyl (2S,3S,4S,5R,6S)-3,4,5-triacetyloxy-6-[4-[6-[tert-butyl(dimethyl)silyl]oxy-3-[4-(2-piperidin-1-ylethoxy)benzoyl]-1-benzothiophen-2-yl]phenoxy]oxane-2-carboxylate
    [2-[4-[tert-butyl(dimethyl)silyl]oxyphenyl]-6-hydroxy-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanone
    [6-[tert-butyl(dimethyl)silyl]oxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanone

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