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Gestrinone

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Origin: China

Cas No: 16320-04-0

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

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CAS No.: 16320-04-0 Formula: C21H24O2 Molecular Weight: 308.41400

Description

Gestrinone (INN, USAN, BAN) (brand names Dimetriose, Dimetrose, Nemestran), also known as ethylnorgestrienone (i.e., ethyl derivative of norgestrienone), is a synthetic steroid of the 19-nortestosterone group that is marketed in Europe, Australia, and Latin America, though not the United States, and is used primarily in the treatment of endometriosis. It is a potent mixed progestogen and antiprogestogen (i.e., partial agonist of the progesterone receptor (PR) or selective progesterone receptor modulator (SPRM)), an antigonadotropin, a mild androgen and anabolic steroid, and a functional antiestrogen. Gestrinone is described as similar in action and effect to danazol, which is also used in the treatment of endometriosis, but is reported to have fewer androgenic side effects in comparison. Because of its anabolic effects, the use of gestrinone in competition has been banned by the International Olympic Committee.

Basic Info

Chemical Name	Gestrinone
Synonyms	D-GESTRINONE; Dimetriose; gestrigone; TridoMose; Dimetrose; NeMestran;
CAS No.	16320-04-0
Molecular Formula	C21H24O2
Molecular Weight	308.41400
PSA	37.30000
LogP	3.72280

Properties

Appearance & Physical State	Light yellow solid
Density	1.18g/cm3
Boiling Point	507.6ºC at 760mmHg
Melting Point	154ºC
Flash Point	214.9ºC
Refractive Index	1.607

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Oral	LDLo - Lowest published lethal dose	Rodent - rat	1 gm/kg	1.Behavioral-altered sleep time (including change in righting reflex) 2.Skin and Appendages-dermatitis, other (after systemic exposure) 3.Nutritional and Gross Metabolic-other changes
Intraperitoneal	LDLo - Lowest published lethal dose	Rodent - rat	1 gm/kg	1.Sense Organs and Special Senses (Eye)-visual field changes 2.Behavioral-altered sleep time (including change in righting reflex) 3.Nutritional and Gross Metabolic-other changes
Intraperitoneal	LDLo - Lowest published lethal dose	Rodent - mouse	1 gm/kg	1.Behavioral-altered sleep time (including change in righting reflex) 2.Behavioral-convulsions or effect on seizure threshold 3.Gastrointestinal-other changes