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Deflazacort

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Origin: China

Cas No: 14484-47-0

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
14484-47-0
Other Names:
11b,21-Dihydroxy-2'-methyl-5'bH-pregna-1,4-dieno[17,16-d]oxazole-3,20-
MF:
C25H31NO6
EINECS No.:
238-483-7
Place of Origin:
Beijing, China
Type:
Auxiliaries and Other Medicinal Chemicals
Grade Standard:
Medicine Grade
Brand Name:
MESOCHEM
Model Number:
14484-47-0
Purity:
99%
Form:
Powder
Molecular Weight:
441.52
Packaging&Delivery
Packaging Details
Export standard packing
Port
Beijing
Lead Time:
Depend on the quantity

Property

CAS No.: 14484-47-0 Formula: C25H31NO6 Molecular Weight: 441.51700

Description

Deflazacort is a glucocorticoid used as an anti-inflammatory and immunosuppressant.
Deflazacort is an inactive prodrug which is metabolized rapidly to the active drug 21-desacetyldeflazacort. Its potency is around 70–90% that of prednisone.
It is sold in Bangladesh as Xalcort, marketed by Beacon Pharmaceuticals Limited, in the United Kingdom by Shire under the trade name Calcort; in Brazil as Cortax, Decortil, and Deflanil; in India as MOAID, ZENFLAV BY TIGRIS, Defolet(Roussette), DFZ, Decotaz, and DefZot; in Panama as Zamen, Spain as Zamene and in Honduras as Flezacor. It is not available in the United States. In January 2015, the FDA granted fast track status to Marathon Pharmaceuticals to pursue approval of deflazacort as a potential treatment for Duchenne muscular dystrophy. The company expects to make deflazacort available in the United States in 2016.

Basic Info

Chemical Name	Deflazacort
Synonyms	11b,21-Dihydroxy-2'-methyl-5'bH-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione 21-acetate; Cortax,Decortil,Deflanil;
CAS No.	14484-47-0
Molecular Formula	C25H31NO6
Molecular Weight	441.51700
PSA	102.26000
LogP	1.99880

Properties

Appearance & Physical State	COA
Density	1.41 g/cm3
Boiling Point	595.4ºC at 760 mmHg
Melting Point	255-256.5ºC
Flash Point	313.9ºC
Refractive Index	1.675
Vapor Pressure	4.13E-14mmHg at 25°C

Safety Info

HS Code	2937290090

Synthesis Route

3β,11β-dihydroxy-2'-methyl-(5α,16β)-pregnano[17,16-d]oxazol-20-one→Deflazacort
11β-hydroxy-2'-methyl-(5α,16β)-pregnano[17,16-d]oxazole-3,20-dione→Deflazacort
3β,11β-dihydroxy-2'-methyl-(5α,16β)-pregnano[17,16-d]oxazol-20-one semicarbazone→Deflazacort

Precursor

3β-hydroxy-2'-methyl-(5α,16β)-pregnano[17,16-d]oxazole-11,20-dione 20-semicarbazone
3β,11β-dihydroxy-2'-methyl-(5α,16β)-pregnano[17,16-d]oxazol-20-one semicarbazone
21-Deacetoxy Deflazacort
11β-hydroxy-2'-methyl-(5α,16β)-pregnano[17,16-d]oxazole-3,20-dione

Downstream Product

21-Desacetyl Deflazacort

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