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9-Nitrocamptothecin

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Origin: China

Cas No: 91421-42-0

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Property

CAS No.: 91421-42-0 Formula: C20H15N3O6 Molecular Weight: 393.35000

Description

Rubitecan (INN, marketing name Orathecin) is an oral topoisomerase inhibitor, developed by Supergen.

Basic Info

Chemical Name	9-Nitrocamptothecin
Synonyms	Rubitecan; 9-NITRO-20(S)-CAMPTOTHECIN; PYRIDOXINE 3,4-DIPALMITATE; 1H-PYRANO[3',4':6,7]INDOLIZINO[1,2-B]QUINOLINE-3,14(4H,12H)-DIONE,4-ETHYL-4-HYDROXY-10-NITRO-, (4S)-;
CAS No.	91421-42-0
Molecular Formula	C20H15N3O6
Molecular Weight	393.35000
PSA	127.24000
LogP	2.51100

Properties

Appearance & Physical State	Yellow amorphous powder
Density	1.63g/cm3
Boiling Point	816.3ºC at 760 mmHg
Melting Point	182-186ºC
Flash Point	447.5ºC
Refractive Index	1.761
Storage Condition	Room temp
Vapor Pressure	3.53E-28mmHg at 25°C

Safety Info

RTECS	UQ0493300

Synthesis Route

4-methoxy-benzenesulfonic acid 4-ethyl-4-hydroxy-10-nitro-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-9-yl ester→9-Nitrocamptothecin
4-bromo-benzenesulfonic acid 4-ethyl-4-hydroxy-10-nitro-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-9-yl ester→9-Nitrocamptothecin
(S)-4-ethyl-4-hydroxy-10-nitro-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl 4-nitrobenzenesulfonate→9-Nitrocamptothecin

Precursor

4-methoxy-benzenesulfonic acid 4-ethyl-4-hydroxy-10-nitro-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-9-yl ester
(S)-4-ethyl-4-hydroxy-10-nitro-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl 4-nitrobenzenesulfonate
(S)-4-ethyl-4-hydroxy-10-nitro-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl benzenesulfonate
4-bromo-benzenesulfonic acid 4-ethyl-4-hydroxy-10-nitro-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-9-yl ester

Downstream Product

camptothecin
9-Methoxycamptothecin
3,4-dihydro-9-hydroxy-2,2-dimethyl-2H-benzo[g]chromene-5,10-dione
9-Aminocamptothecin

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