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norethisterone

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Origin: China

Cas No: 68-22-4

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
68-22-4
Other Names:
19-Norethisterone
MF:
C20H26O2
EINECS No.:
200-681-6
Place of Origin:
Beijing, China
Type:
Contraceptive Agents
Grade Standard:
Medicine Grade, Tech Grade
Brand Name:
Yibai
Model Number:
68-22-4
Purity:
98.0~102.0%
Product Name:
Norethindrone
Appearance:
white to off white crystalline powder
COA:
AVALIABLE
Assay:
98.0~102.0%
resudue on igniton:
0.5%
Shelf life:
3 Years
Total Impurities:
≤2.0%
Quality:
USP
Grade:
Phamaceutical Grade
Production Capacity:
200kg/month
Packaging&Delivery
Packaging Details
Bulk qty: 25kg/drum, inside two level plastic bags
Small qty: Aluminium bag, inside two level plastic bags
Others: can do your package or split small packages according to your request
Port
Beijing, Shanghai, Shenzhen
Lead Time:
Quantity(Grams) 1 - 50000 >50000
Est. Time(days) 5 To be negotiated

Property

CAS No.: 68-22-4 Formula: C20H26O2 Molecular Weight: 298.41900

Description

Norethisterone (INN, BAN), also known as norethindrone (USAN), as well as 19-nor-17α-ethynyltestosterone, but more commonly known under its trade name Utovlan®, is a steroidal progestin used in some combined oral contraceptive pills and progestogen-only pills, and also available as a standalone drug. It can be used to treat premenstrual syndrome, painful periods, abnormal heavy bleeding, irregular periods, menopausal syndrome (in combination with estrogen), or to postpone a period. It is also commonly used to help prevent uterine hemorrhage in complicated non-surgical or pre-surgical gynecologic cases and in treating non responsive cyclical mastalgia. Norethisterone was the first orally highly active progestin to be synthesized.
It was synthesized for the first time by chemists Luis Miramontes, Carl Djerassi, and George Rosenkranz at Syntex in Mexico City in 1951. It was the progestin used in one of the first three oral contraceptives. Its related ester, norethisterone acetate, is used for the same indications. Norethisterone was first introduced, as Norlutin, in 1957.

Basic Info

Chemical Name	norethisterone
Synonyms	Mini-Pe; NET; Gestest; ENT; Norethindrone; Noriday; Anovule; Norfor; sc4640; 19-Norpregn-4-en-20-yn-3-one, 17-hydroxy-, (17 -)-; triella;
CAS No.	68-22-4
Molecular Formula	C20H26O2
Molecular Weight	298.41900
PSA	37.30000
LogP	3.49250

Properties

Appearance & Physical State	Off-White to Pale Yellow Solid
Density	1.15 g/cm3
Boiling Point	447ºC at 760 mmHg
Melting Point	205-206ºC
Refractive Index	1.577
Storage Condition	-20ºC Freezer

Safety Info

RTECS	RC8975000
Safety Statements	S22; S36/37/39; S45; S26
HS Code	2937290090
WGK Germany	3
Risk Statements	R40
Hazard Codes	Xn
Symbol	GHS08
Hazard Declaration	H351
Signal Word	Warning

Synthesis Route

(8R,9S,13S,14S,17R)-17-ethynyl-17-hydroxy-13-methyl-1,2,4,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one→norethisterone
Nandrolone→norethisterone
Norandrostenedione→norethisterone

Precursor

Norandrostenedione
Nandrolone
acetylene
(8R,9S,13S,14S,17R)-17-ethynyl-17-hydroxy-13-methyl-1,2,4,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one

Downstream Product

6-Oxo Norethindrone
Lynestrenol
17α-ethynylestradiol
(8R,9S,10R,13S,14S,17S)-17-ethyl-17-hydroxy-13-methyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one

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