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norethisterone acetate

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Origin: China

Cas No: 51-98-9

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

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Product Description

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CAS No.: 51-98-9 Formula: C22H28O3 Molecular Weight: 340.45600

Description

Progesteron. Norethindrone and acetate in combination with estrogen as contraceptive (oral). It is reasonably anticipated to be a human carcinogen.

Basic Info

Chemical Name	norethisterone acetate
Synonyms	19-Nor-17α-ethynyltestosterone Acetate; Norethisterone Acetate; 19-Norethindrone acetate; [(8R,9S,10R,13S,14S,17R)-17-ethynyl-13-methyl-3-oxo-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-yl] acetate; 17α-Ethynyl-19-nortestosterone Acetate;
CAS No.	51-98-9
Molecular Formula	C22H28O3
Molecular Weight	340.45600
PSA	43.37000
LogP	4.06330

Properties

Density	1.14 g/cm3
Boiling Point	454.7ºC at 760 mmHg
Flash Point	197.1ºC
Refractive Index	-34 ° (C=1, Dioxane)

Safety Info

RTECS	RC8965000
Safety Statements	S36/37
HS Code	2915299090
WGK Germany	3
Risk Statements	R40; R48
Hazard Codes	Xn

Synthesis Route

norethisterone+acetic acid→norethisterone acetate
norethisterone+Acetic anhydride→norethisterone acetate
3,17-diacetoxy-19-nor-17βH-pregna-3,5-dien-20-yne→norethisterone acetate

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Oral	TDLo - Lowest published toxic dose	Rodent - rat	303 ug/kg/2Y-C	1.Tumorigenic-equivocal tumorigenic agent by RTECS criteria 2.Liver-tumors 3.Nutritional and Gross Metabolic-weight loss or decreased weight gain
Oral	TDLo - Lowest published toxic dose	Human - woman	2190 ug/kg,female 52 week(s) pre-mating	1.Reproductive-Fertility-female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
Oral	TDLo - Lowest published toxic dose	Human - woman	2 mg/kg,female 20 day(s) pre-mating	1.Reproductive-Maternal Effects-menstrual cycle changes or disorders