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N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]formamide

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Origin: China

Cas No: 7411-12-3

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

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CAS No.: 7411-12-3 Formula: C21H23NO6 Molecular Weight: 385.41000

Description

Colchicine derivative. A new alkaloid from Gloriosa superba.

Basic Info

Chemical Name	N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]formamide
Synonyms	Formyldescaetylcolchicine,N; (S)-7-Formylamino-1,2,3,10-tetramethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-on; N-Formyldesacetylcolchicine; N-Formyldeacetylcolchicine; COLCHICINE,N-DEACETYL-N-FORMYL; N-((S)-1,2,3,10-Tetramethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-formamid; N-((S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-formamide; N-formyl-N-deacetylcolchicine; N-Desacetyl-N-formyl-colchicin; N-deacetyl-N-formylcolchicine; Gloriosine;
CAS No.	7411-12-3
Molecular Formula	C21H23NO6
Molecular Weight	385.41000
PSA	83.09000
LogP	3.50830

Properties

Density	1.27g/cm3
Boiling Point	715.8ºC at 760 mmHg
Melting Point	264-267ºC
Flash Point	386.7ºC
Refractive Index	1.591
Storage Condition	-20ºC Freezer, Under Inert Atmosphere

Safety Info

HS Code	2924299090

Synthesis Route

formic acid+Benzo[a]heptalen-9(5H)-one,7-amino-6,7-dihydro-1,2,3,10-tetramethoxy-, (7S)-→N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]formamide
diazomethane→N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]formamide

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Subcutaneous	LDLo - Lowest published lethal dose	Rodent - rat	2 mg/kg	1.Details of toxic effects not reported other than lethal dose value
Intravenous	LD50 - Lethal dose, 50 percent kill	Rodent - rat	4400 ug/kg	1.Behavioral-somnolence (general depressed activity) 2.Behavioral-muscle weakness 3.Gastrointestinal-hypermotility, diarrhea
Intraperitoneal	LD50 - Lethal dose, 50 percent kill	Rodent - mouse	2666 ug/kg	1.Tumorigenic-active as anti-cancer agent

Precursor

diazomethane
Benzo[a]heptalen-9(5H)-one,7-amino-6,7-dihydro-1,2,3,10-tetramethoxy-, (7S)-
formic acid

Downstream Product

Benzo[a]heptalen-9(5H)-one,7-amino-6,7-dihydro-1,2,3,10-tetramethoxy-, (7S)-
1,2,3,10-tetramethoxy-5,6-dihydrobenzo[a]heptalene-7,9-dione

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