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N-[1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl]formamide

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Origin: China

Cas No: 84467-85-6

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 84467-85-6 Formula: C16H22ClNO Molecular Weight: 279.80500

Description

An intermediate of a Sibutramine metabolite, a serotonin and noradrenaline reuptake inhibitor (SNR). Decreases calorie intake and increases energy expenditure.

Basic Info

Chemical Name	N-[1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl]formamide
Synonyms	N-Formyl N,N-Didesmethyl Sibutramine; FOR004;
CAS No.	84467-85-6
Molecular Formula	C16H22ClNO
Molecular Weight	279.80500
PSA	32.59000
LogP	4.76270

Properties

Density	1.102g/cm3
Boiling Point	425.7ºC at 760 mmHg
Flash Point	211.2ºC
Refractive Index	1.536

Synthesis Route

(Z)-Methanimidic acid+1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutan-1-one→N-[1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl]formamide
1-(4-chlorophenyl)cyclobutane-1-carbonitrile→N-[1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl]formamide
4-chlorophenylacetonitrile→N-[1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl]formamide

Precursor

1-(4-chlorophenyl)cyclobutane-1-carbonitrile
1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutan-1-one
1-(1-(4-chlorophenyl)cyclobutyl)-3-methylbutan-1-imine
(Z)-Methanimidic acid

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N-[1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl]formamide

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