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microcystin-LR

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Origin: China

Cas No: 101043-37-2

Specification: 99%min

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Supply Ability: 80 mt/month

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 101043-37-2 Formula: C49H74N10O12 Molecular Weight: 995.17200

    Description

    Microcystin-LR (MC-LR) is a toxin produced by cyanobacteria. It is the most toxic of the microcystins.
    Microcystins are cyclic heptapeptides. The seven amino acids that are involved in the structure of a microcystin include a unique β-amino acid (ADDA). It contains alanine (D-ala), D-β-methyl-isoaspartate (D-β-Me-isoAsp), and glutamic acid (D-glu). Furthermore, microcystins contain two variable residues, which make the differentiation between variants of microcystins. These two variable elements are always standard L-amino acids. In microcystin-LR these are leucine and arginine.
    Eighty microcystins have been identified to date, representing differences in the two variable residues and some modifications in the other amino acids. These modifications include demethylation of Masp and Mdha and methylesterification of D-Glu. Different microcystins have different toxicity profiles, with microcystin-LR found to be the most toxic.
    Toxicity of cyanotoxins is very diverse and include neurotoxicity, hepatotoxicity, cytotoxicity and dermatotoxicity. Microcystins are generally associated with hepatotoxicity. The toxic effect of microcystins is due to their inhibition of protein phosphatases.

    Basic Info

    Chemical Name microcystin-LR
    Synonyms

    5-L-Arginine-cyanoginosin;
    akerstox;
    TOXIN,BLUE-GREENALGA;
    Microcystin-LR;
    microcystin-lr solution;
    5-L-Arginine-microcystin LA;
    toxin-lr;
    microcystin-a;
    microcystin LR;
    MCYST-LR;
    CYANOGINOSIN-LR;

    CAS No. 101043-37-2
    Molecular Formula C49H74N10O12
    Molecular Weight 995.17200
    PSA 340.64000
    LogP 3.92970

    Properties

    Density 1.29g/cm3
    Refractive Index 1.598
    Storage Condition -20ºC

    Safety Info

    RIDADR UN 2811 6.1/PG 1
    Risk Statements R26/27/28; R36/37/38; R43
    Hazard Codes T+

    Synthesis Route

    →microcystin-LR

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Intraperitoneal LD50 - Lethal dose, 50 percent kill Rodent - rat 50 ug/kg 1.Details of toxic effects not reported other than lethal dose value
    Unreported LD50 - Lethal dose, 50 percent kill Rodent - rat 50 ug/kg 1.Cardiac-other changes
    2.Liver-hepatitis (hepatocellular necrosis), zonal
    3.Kidney, Ureter, Bladder-changes in tubules (including acute renal failure, acute tubular necrosis)
    Inhalation LC50 - Lethal concentration, 50 percent kill Rodent - mouse 18 mg/m3/10M 1.Details of toxic effects not reported other than lethal dose value

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