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Inosine

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Origin: China

Cas No: 58-63-9

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

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Products Specification
Product Description

Quick Details
CAS No.:
58-63-9
Other Names:
Inosine
MF:
C10H12N4O5
EINECS No.:
200-390-4
Place of Origin:
Shandong, China
Type:
Auxiliaries and Other Medicinal Chemicals
Grade Standard:
Medicine Grade
Usage:
Animal Pharmaceuticals
Brand Name:
xigema
Model Number:
TOP
Purity:
99%min
Product Name:
Inosine
Appearance:
White Powder
CAS:
58-63-9
Name:
Inosine
Grade:
Medicine Grade
Assay:
99%
Certificate:
ISO
Shelf life:
2 Years
Application:
Pharmaceutical Raw Intermediates
Color:
White Color
Packaging&Delivery
Packaging Details
25kg/drum
Port
QINGDAO PORT

Property

CAS No.: 58-63-9 Formula: C10H12N4O5 Molecular Weight: 268.22600

Description

Inosine is a nucleoside that is formed when hypoxanthine is attached to a ribose ring (also known as a ribofuranose) via a β-N9-glycosidic bond.
Inosine is commonly found in tRNAs and is essential for proper translation of the genetic code in wobble base pairs.
Knowledge of inosine metabolism has led to advances in immunotherapy in recent decades. Inosine monophosphate is oxidised by the enzyme inosine monophosphate dehydrogenase, yielding xanthosine monophosphate, a key precursor in purine metabolism. Mycophenolate mofetil is an anti-metabolite, anti-proliferative drug that acts as an inhibitor of inosine monophosphate dehydrogenase. It is used in the treatment of a variety of autoimmune diseases including granulomatosis with polyangiitis because the uptake of purine by actively dividing B cells can exceed 8 times that of normal body cells, and, therefore, this set of white cells (which cannot operate purine salvage pathways) is selectively targeted by the purine deficiency resulting from inherited metabolic diseases (IMD) inhibition.

Basic Info

Chemical Name	Inosine
Synonyms	6-Oxopurine riboside; nosine; Inosine; Ino; 6-oxy-purine riboside; HXR; (−)-Inosine; Selfer; hypoxanthine; Atorel; INO 495; RIBOXINE; Oxiamin; Inosie;
CAS No.	58-63-9
Molecular Formula	C10H12N4O5
Molecular Weight	268.22600
PSA	133.49000
LogP	-2.26890

Properties

Appearance & Physical State	white powder.
Density	2.08 g/cm3
Boiling Point	732.8ºC at 760 mmHg
Melting Point	212-213ºC
Flash Point	397ºC
Refractive Index	-52 ° (C=1, H2O)
Water Solubility	2.1 g/100 mL (20 ºC)
Stability	Stable under normal temperatures and pressures.
Storage Condition	Store at RT.

Safety Info

RTECS	NM7460000
Safety Statements	S24/25
HS Code	2934999090
WGK Germany	2
Risk Statements	R36/37/38
Hazard Codes	Xi

Synthesis Route

9H-Purine, 6-hydrazino-9-.β.-D-ribofuranosyl-→Inosine+nebularine
3'-O-(acetyloxymethyl)adenosin-2'-yl adenosin-5'-yl 3-(acetyloxy)-2,2-bis(ethoxycarbonyl)propyl phosphate→diethyl 2-(acetoxymethyl)-2-((((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl)oxy)(hydroxy)phosphoryl)oxy)methyl)malonate+diethyl 2-(acetoxymethyl)-2-((((((2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-3-yl)oxy)(hydroxy)phosphoryl)oxy)methyl)malonate
3-(acetyloxy)-2,2-bis(ethoxycarbonyl)propyl adenosin-5'-yl 3'-O-(pivaloyloxymethyl)adenosin-2'-yl phosphate→diethyl 2-(acetoxymethyl)-2-((((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl)oxy)(hydroxy)phosphoryl)oxy)methyl)malonate+diethyl 2-(acetoxymethyl)-2-((((((2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-3-yl)oxy)(hydroxy)phosphoryl)oxy)methyl)malonate

Precursor

adenosine
6-Methoxypurine ribonucleoside
2',3',5'-Tri-O-acetylinosine
6-Chloropurine-9-riboside

Downstream Product

2',3',5'-Tri-O-acetylinosine
1-(6-Chloro-9H-purin-9-yl)-1-deoxy-2,3-O-(1-methylethylidene)-b-D-Ribofuranuronoyl chloride
hypoxanthine
aldehydo-D-ribose

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