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3-O-methyl 5-O-(2-oxopropyl) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

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Origin: China

Cas No: 86780-90-7

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

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CAS No.: 86780-90-7 Formula: C19H20N2O7 Molecular Weight: 388.37100

Description

Aranidipine (INN, trade name Sapresta) is a calcium channel blocker.

Basic Info

Chemical Name	3-O-methyl 5-O-(2-oxopropyl) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Synonyms	Mpc-1304; Sapresta; aranidipine;
CAS No.	86780-90-7
Molecular Formula	C19H20N2O7
Molecular Weight	388.37100
PSA	127.52000
LogP	2.98680

Properties

Density	1.284 g/cm3
Boiling Point	530ºC at 760 mmHg
Flash Point	274.3ºC
Refractive Index	1.555

Synthesis Route

2,2-ethylenedioxypropyl methyl 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylate→3-O-methyl 5-O-(2-oxopropyl) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
3-amino-2-crotonic acid 2,2-ethylenedioxy propyl ester→3-O-methyl 5-O-(2-oxopropyl) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
2,2-ethylenedioxypropyl acetoacetate→3-O-methyl 5-O-(2-oxopropyl) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Oral	LD50 - Lethal dose, 50 percent kill	Rodent - rat	1459 mg/kg	1.Behavioral-convulsions or effect on seizure threshold 2.Blood-normocytic anemia 3.Nutritional and Gross Metabolic-body temperature decrease
Oral	LD50 - Lethal dose, 50 percent kill	Rodent - mouse	143 mg/kg	1.Behavioral-convulsions or effect on seizure threshold 2.Lungs, Thorax, or Respiration-respiratory depression 3.Blood-normocytic anemia
Intraperitoneal	LD50 - Lethal dose, 50 percent kill	Rodent - mouse	7300 ug/kg	1.Behavioral-convulsions or effect on seizure threshold 2.Lungs, Thorax, or Respiration-respiratory depression 3.Blood-normocytic anemia

Precursor

3-amino-2-crotonic acid 2,2-ethylenedioxy propyl ester
2,2-ethylenedioxypropyl acetoacetate
Methyl acetoacetate
METHYL 2-(O-NITROBENZYLIDENE)-ACETOACETATE

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