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N-ethylmaleimide

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Origin: China

Cas No: 128-53-0

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

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CAS No.: 128-53-0 Formula: C6H7NO2 Molecular Weight: 125.12500

Description

N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.

Basic Info

Chemical Name	N-ethylmaleimide
Synonyms	1-ethyl-1H-pyrrole-2,5-dione; ethvlmaleimide; N-Ethylmaleimide; n-ethyl-maleimid; 1H-Pyrrole-2,5-dione, 1-ethyl-; 1-ethylmaleimide; N-ethyl-maleimide; Ethylmaleimide; N-Ethylmaleinimid; N-ethylmaleic imide; n-ethvlmaleimide;
CAS No.	128-53-0
Molecular Formula	C6H7NO2
Molecular Weight	125.12500
PSA	37.38000
LogP	-0.13080

Properties

Appearance & Physical State	White solid
Density	1.207 g/cm3
Boiling Point	210ºC
Melting Point	41-45ºC
Flash Point	73ºC
Refractive Index	1.514
Water Solubility	1 g/L (20 ºC)
Stability	Stable. Combustible. Incompatible with strong oxidizing agents. Refrigerate.
Storage Condition	2-8ºC
Vapor Pressure	0.197mmHg at 25°C

Safety Info

RTECS	UX9625000
Hazard Class	6.1
Safety Statements	S26-S28-S36/37/39-S45
HS Code	2925190090
WGK Germany	3
Packing Group	II
RIDADR	UN 2928
Risk Statements	R20/21; R28; R34; R43
Hazard Codes	T+
Hazard Declaration	H300; H311; H314; H317
Signal Word	Danger
Caution Statement	P264; P280; P301 + P310; P305 + P351 + P338; P310
Symbol	GHS05, GHS06

Synthesis Route

maleic anhydride+Ethylamine Hydrochloride→N-ethylmaleimide
N-ETHYLMALEAMIC ACID→N-ethylmaleimide
diethyl 4,4'-((3aR,4R,7S,7aS)-2-ethyl-1,3-dioxo-2,3,3a,4,7,7ahexahydro-1H-4,7-epoxyisoindole-5,6-diyl)bis(5-methylthiophene-2-carboxylate)→N-ethylmaleimide+

Precursor

diethyl 4,4'-((3aR,4R,7S,7aS)-2-ethyl-1,3-dioxo-2,3,3a,4,7,7ahexahydro-1H-4,7-epoxyisoindole-5,6-diyl)bis(5-methylthiophene-2-carboxylate)
4-(ethylamino)-4-oxobut-2-enoic acid
Ethylamine Hydrochloride
maleic anhydride

Downstream Product

3-(1-ethylpyrrolidin-3-yl)-1H-indole
NSC376728
N-ethylsuccinimide
N-ETHYLMALEAMIC ACID

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