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Home > All categories> Biochemicals and Pharmaceutical Chemicals> Pharmaceutical Impurities> N-[4-(4-Fluorophenyl)-5-formyl-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-methanesulfonamide
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N-[4-(4-Fluorophenyl)-5-formyl-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-methanesulfonamide

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Origin: China

Cas No: 147118-37-4

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Quick Details

    CAS No.:
    147118-37-4
    Other Names:
    Rosuvastatin intermediate R-1-3
    MF:
    C16H18FN3O3S
    EINECS No.:
    604-564-4
    Place of Origin:
    Shaanxi, China
    Type:
    Agrochemical Intermediates, Dyestuff Intermediates, Flavor & Fragrance Intermediates, Pharmaceutical Intermediates, Syntheses Material Intermediates
    Purity:
    99%min
    Brand Name:
    DIDAC
    Model Number:
    DAC170112
    Application:
    Pharm/Chem Industries
    Appearance:
    Solid Form
    Structure Identification:
    H-NMR&LC-MS
    Identification:
    Infrared Absorption
    Test method:
    HPLC-ESI-MS
    Content:
    99.0% to 101.0%
    Water:
    0.5% Max.
    Sulfated ash:
    0.1% Max.
    Heavy metals:
    10ppm Max
    Total Impurity:
    0.2% Max.
    Assay:
    HPLC
    Disregard limit:
    0.0005%

    Packaging&Delivery

    Packaging Details
    25kgs/Drum; 200kgs/Drum
    Port
    Any main port of China
    Lead Time:
    Quantity(Grams) 1 - 1 >1
    Est. Time(days) 3 To be negotiated

    Products Description

    Item
    Standard
    Test Results
     
     
     
     
     
    Identification
    A.H-NMR:Comply with the structure
    Complies
     
    B.LC-MS:Comply with the structure
    Complies
     
    C.The IR spectrum of sample should be identical with that of reference standard;
    Complies
     
    D.HPLC-ESI-MS
    The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the
    Standard preparation, as obtained in the Assay.
    Complies
    Crystallinity
    meets the requirements.
    Complies
    Loss on drying
    ≤2.0%
    0.19%
    Heavy metals
    ≤10 ppm
    <10ppm
    Water
    ≤1.0%
    0.1%
    Sulphated ash
    ≤0.5%, determined on 1.0 g.
    0.009%
     
    Related substances
    Unspecified impurities: for each impurity ≤0.10%
    <0.10%
     
    Total Impurity ≤0.5%
    0.18%
    Purity
    ≥99.0%
    99.7%
    Assay
    99.0%~101.0% (anhydrous substance).
    99.8%
    Storage
    Preserve in well-closed, light-resistant and airtight containers.
    Complies
  •  

    Property

    CAS No.: 147118-37-4 Formula: C16H18FN3O3S Molecular Weight: 351.39600
     

    Description

    Rosuvastatin intermediate.
     

    Basic Info

    Chemical Name N-[4-(4-Fluorophenyl)-5-formyl-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-methanesulfonamide
    Synonyms

    4-(4-Fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulphonylamino)pyrmidine-5-carboxaldehyde;
    4-(4-Fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesulfonylamino)-5-pyrimidinecarboxaldehyde;
    4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidinyl-5-yl-formyl;
    CAS No. 147118-37-4
    Molecular Formula C16H18FN3O3S
    Molecular Weight 351.39600
    PSA 88.61000
    LogP 3.69520
     

    Properties

    Density 1.32 g/cm3
    Boiling Point 536.594ºC at 760 mmHg
    Flash Point 278.322ºC
    Refractive Index 1.575
    Vapor Pressure 0mmHg at 25°C
     

    Safety Info

    HS Code 2935009090
     

    Synthesis Route

    N-[5-Bromomethyl-4-(4-fluorophenyl)-6-isopropylpyrimidine-2-yl]-N-methylmethane sulfonamide→4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsufonyl)amino]pyrimidine-5-yl-methanol+N-[4-(4-Fluorophenyl)-5-formyl-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-methanesulfonamide
    1-(4-fluorophenyl)-2-methyl-3-isopropylpropan-1,3-dione→4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsufonyl)amino]pyrimidine-5-yl-methanol+N-[4-(4-Fluorophenyl)-5-formyl-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-methanesulfonamide
    1-(4-fluorophenyl)-4-methylpentane-1,3-dione→4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsufonyl)amino]pyrimidine-5-yl-methanol+N-[4-(4-Fluorophenyl)-5-formyl-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-methanesulfonamide
     

    Precursor

    4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsufonyl)amino]pyrimidine-5-yl-methanol
    N-(4-(4-fluorophenyl)-6-isopropyl-5-(prop-1-enyl)pyrimidin-2-yl)-N-methylmethanesulfonamide
    N-[5-[1,3]dioxolane-2-yl-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
    N-[5-Bromomethyl-4-(4-fluorophenyl)-6-isopropylpyrimidine-2-yl]-N-methylmethane sulfonamide
     

    Downstream Product

    tert-Butyl 6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate
    methyl (E,3R,5S)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-propan-2-ylpyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate
    4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsufonyl)amino]pyrimidine-5-yl-methanol
    Rosuvastatin

Hot tags: n-[4-(4-fluorophenyl)-5-formyl-6-(1-methylethyl)-2-pyrimidinyl]-n-methyl-methanesulfonamide, China, manufacturers, suppliers, factory, wholesale, low price, high quality
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