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chloral hydrate

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Origin: China

Cas No: 302-17-0

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

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Product Description

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CAS No.: 302-17-0 Formula: C2H3Cl3O2 Molecular Weight: 165.40300

Description

Trichloroacetaldehyde hydrate is a useful chemical reagent used as a sedative/hypnotic agent. Studies have shown that when used in pediatric sedation side effects such as hallucination, excessive sleep and seizures were observed. It is sometimes administered to patients being treated with cyclophosphamide and it is known to inhibit some aldehyde dehydrogenases.

Basic Info

Chemical Name	chloral hydrate
Synonyms	Trichloroacetaldehyde Hydrate; 1,1-Ethanediol, 2,2,2-trichloro-; Tosyl; bi3411; Hynos; 1,1-dihydroxy-2,2,2-trichloroethane; trichloroacetaldehyde monohydrate; Chloral hydrate; 2,2,2-trichloro-1,1-ethanediol; Nortec; Dormal; Escre; Hydral; 2,2,2-Trichloroethane-1,1-diol; 2,2,2-trichloroacetaldehyde monohydrate; Noctec; TCA;
CAS No.	302-17-0
Molecular Formula	C2H3Cl3O2
Molecular Weight	165.40300
PSA	40.46000
LogP	0.66730

Properties

Appearance & Physical State	white crystalline powde
Density	1.908
Boiling Point	97ºC
Melting Point	57ºC
Flash Point	57.3ºC
Water Solubility	660 g/100 mL
Stability	Stable, but may be air or light sensitive. Incompatible with alcohols, cyanides, iodine, strong bases, carbonates.
Storage Condition	0-6°C

Safety Info

RTECS	FM8750000
Hazard Class	6.1(b)
Safety Statements	S25-S45
HS Code	2913000010
WGK Germany	2
Packing Group	III
RIDADR	UN 2075
Risk Statements	R25; R36/38
Hazard Codes	T

Synthesis Route

N-(2,2,2-trichloro-1-p-chlorobenzenesulfonamidoethyl)-p-chlorobenzenesulfonamide→4-Chlorobenzenesulfonamide+chloral hydrate
1-bornyloxy-2,2,2-trichloro-ethanol+Water→chloral hydrate+DL-2-Bornanol
trichloroethene→2,2,2-trichloroethanol+chloral hydrate

GC Analysis

Column type	Active phase	Temperature (°C)	Retention Index (I)	Temperature Control Method
Capillary	SPB-1	-	698.	custom temperature program
Capillary	SPB-1	-	698.	custom temperature program
Capillary	SPB-1	-	705.	custom temperature program
Capillary	OV-1	-	695.	custom temperature program

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Oral	TDLo - Lowest published toxic dose	Human - man	1 gm/kg	1.Behavioral-coma 2.Cardiac-pulse rate increase, without fall in BP 3.Lungs, Thorax, or Respiration-cyanosis
Oral	TDLo - Lowest published toxic dose	Human - child	219 mg/kg	1.Cardiac-arrhythmias (including changes in conduction)
Oral	TDLo - Lowest published toxic dose	Human - woman	960 mg/kg	1.Behavioral-somnolence (general depressed activity) 2.Behavioral-hallucinations, distorted perceptions 3.Cardiac-pulse rate increase, without fall in BP