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7-Chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

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Origin: China

Cas No: 68077-26-9

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Property

CAS No.: 68077-26-9 Formula: C12H9ClFNO3 Molecular Weight: 269.65600

Description

Norfloxacin intermediate.

Basic Info

Chemical Name	7-Chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
Synonyms	7-chloro-1-ethyl-6-fluoro-4-oxoquinoline-3-carboxylic acid;
CAS No.	68077-26-9
Molecular Formula	C12H9ClFNO3
Molecular Weight	269.65600
PSA	59.30000
LogP	2.51210

Properties

Appearance & Physical State	White powder
Density	1.489 g/cm3
Boiling Point	437.9ºC at 760 mmHg
Melting Point	279-281ºC
Flash Point	218.7ºC

Safety Info

Safety Statements	S61
HS Code	2933499090
Risk Statements	R52/53

Synthesis Route

ethyl 7-chloro-1-ethyl-6-fluoro-4-oxoquinoline-5-carboxylate→7-Chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
N-(3-Chlor-4-fluor-phenyl)-N-ethyl-aminomethylen-meldrumsaeure→7-Chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
ethyl 7-chloro-6-fluoro-4-oxo-1H-quinoline-3-carboxylate→7-Chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

Precursor

ethyl 7-chloro-1-ethyl-6-fluoro-4-oxoquinoline-5-carboxylate
N-(3-Chlor-4-fluor-phenyl)-N-ethyl-aminomethylen-meldrumsaeure
ethyl 7-chloro-6-fluoro-4-oxo-1H-quinoline-3-carboxylate
3-Chloro-4-fluoroaniline

Downstream Product

norfloxacin
7-chloro-1-ethyl-1,4-dihydro-4-oxo-6-(1-piperazinyl)quinoline-3-carboxylic acid
7-chloro-1-ethyl-6-fluoro-2,3-dihydroquinolin-4-one
1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid

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