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[6-methoxy-2-(4-methoxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanone

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Origin: China

Cas No: 84541-38-8

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

Property

CAS No.: 84541-38-8 Formula: C30H31NO4S Molecular Weight: 501.63600

Description

An intermediate in the synthesis of Raloxifene, a nonsteroidal estrogen receptor mixed agonist/antagonist.

Basic Info

Chemical Name	[6-methoxy-2-(4-methoxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanone
Synonyms	1-(2-{4-[6-Methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenoxy}-ethyl)-piperidin; 6-methoxy-2-(4-methoxyphenyl)-3-[4-(2-piperidinoethoxy)benzoyl]benzo[b]thiophene; (4-(2-(piperidin-1-yl)ethoxy)phenyl)(6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl)methanone; 1-(2-{4-[6-methoxy-2-(4-methoxyphenyl)-benzo[b]thiophene-3-carbonyl]-phenoxy}-ethyl)-piperidine; [6-Methoxy-2-(4-methoxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone; [6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene][4-(2-(piperidin-1-yl)ethoxy)phenyl]methanone; 6-methoxy-2-(4-methoxyphenyl)-3-[4-(2-piperidinylethoxy)benzoyl]benzo[b]thiophene; Raloxifene Bismethyl Ether;
CAS No.	84541-38-8
Molecular Formula	C30H31NO4S
Molecular Weight	501.63600
PSA	76.24000
LogP	6.61910

Properties

Melting Point	75-85ºC
Storage Condition	-20ºC Freezer, Under Inert Atmosphere

Synthesis Route

[6-Methoxy-2-(4-methoxyphenyl)-1-benzothiophen-3-yl]{4-[2-(1-pipe ridinyl)ethoxy]phenyl}methanone hydrochloride (1:1)→[6-methoxy-2-(4-methoxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanone
[6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl](4-hydroxyphenyl)methanone+1-(2-chloroethyl)piperidine,hydrochloride→[6-methoxy-2-(4-methoxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanone
2-(piperidin-1-yl)ethanol+6-methoxy-2-(4-methoxyphenyl)-3-(4-fluorobenzoyl)benzo[b]thiophene→[6-methoxy-2-(4-methoxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanone

Precursor

6-methoxy-2-(4-methoxyphenyl)-3-(4-fluorobenzoyl)benzo[b]thiophene
2-(piperidin-1-yl)ethanol
1-(2-chloroethyl)piperidine,hydrochloride
[6-Methoxy-2-(4-methoxyphenyl)-1-benzothiophen-3-yl]{4-[2-(1-pipe ridinyl)ethoxy]phenyl}methanone hydrochloride (1:1)

Downstream Product

raloxifene
[6-Methoxy-2-(4-methoxyphenyl)-1-benzothiophen-3-yl]{4-[2-(1-pipe ridinyl)ethoxy]phenyl}methanone hydrochloride (1:1)

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