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4'-demethylepipodophyllotoxin

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Origin: China

Cas No: 6559-91-7

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Quick Details
CAS No.:
High Quality 4'-Demethylepipodophyllotoxin 6559-91-7
Other Names:
High Quality 4'-Demethylepipodophyllotoxin 6559-91-7
MF:
High Quality 4'-Demethylepipodophyllotoxin 6559-91-7
EINECS No.:
High Quality 4'-Demethylepipodophyllotoxin 6559-91-7
Place of Origin:
China
Type:
Anesthetic Agents, Anti-Allergic Agents, Antibiotic and Antimicrobial Agents, Antidote, Antineoplastic Agents, Antiparasitic Agents, Antipyretic Analgesics and NSAIDs, Auxiliaries and Other Medicinal Chemicals, Blood System Agents, Cardiovascular Agents, Central Nervous System Agents, Disinfectant and Preservatives, Electrolyte Balance and Dialysis Agents, Endocrine System Agents, Gastrointestinal Agents, Immune Function Agents, Respiratory System Agents, Urinary System Agents, Vitamins, Amino Acids and Coenzymes
Grade Standard:
Cosmetic Grade, Feed Grade, Food Grade, Tech Grade
Brand Name:
High Quality 4'-Demethylepipodophyllotoxin 6559-91-7
Model Number:
High Quality 4'-Demethylepipodophyllotoxin 6559-91-7
Purity:
High Quality 4'-Demethylepipodophyllotoxin 6559-91-7
Form:
Powder
Packaging&Delivery
Packaging Details
25kg/drum
Port
Shanghai

Property

CAS No.: 6559-91-7 Formula: C21H20O8 Molecular Weight: 400.37900

Description

A potent inhibitor of microtubule assembly.

Basic Info

Chemical Name	4'-demethylepipodophyllotoxin
Synonyms	4'-DEMETHYLEPIPODOPHYLLOTOXINE; 4'-DMEP; 4-DEMETHYL EIPODOPHYLLOTOXIN; 4-Domethylpodophyllotoxin,4'-demethyl-epi-Podophyllotoxin; 4'-Demethylepipodophyllotoxin; 4'-demethyl-9-epipodophyllotoxin; 4'-O-demethylepipodophyllotoxin; 4'-demethyl-epipodophyllotoxin; 4'-demethyl-4-epipodophyllotoxin;
CAS No.	6559-91-7
Molecular Formula	C21H20O8
Molecular Weight	400.37900
PSA	103.68000
LogP	2.10620

Properties

Appearance & Physical State	White crystalline powder
Density	1.446 g/cm3
Boiling Point	626.5ºC at 760 mmHg
Melting Point	246-248ºC
Flash Point	224.4ºC
Refractive Index	1.616
Storage Condition	-20ºC Freezer

Synthesis Route

podophyllotoxin→4'-demethylepipodophyllotoxin
podophyllotoxin→4'-demethylepipodophyllotoxin+(5R,5aR,8aR,9S)-9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tet rahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
4'-O-demethyl-4β-bromo-4-desoxypodophyllotoxin→4'-demethylepipodophyllotoxin

Precursor

4,4'-bis(tert-butyldimethylsilyl)-4'-O-demethylepipodophyllol
(5R,5aR,8aR,9S)-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-iodo-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
4'-O-demethyl-4β-bromo-4-desoxypodophyllotoxin
4β-bromo-4-desoxypodophyllotoxin

Downstream Product

(5R,5aR,8aR)-5-(4-hydroxy-3,5-dimethoxyphenyl)-5a,8,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-6-one
(5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-5-(4-hydroxyphenyl)sulfanyl-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one
etoposide
(5S,5aR,8aR,9R)-9-(4-Hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8, 8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl β-D-g lucopyranoside

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