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3-Maleimidobenzoic acid N-hydroxysuccinimide ester

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Origin: China

Cas No: 58626-38-3

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 58626-38-3 Formula: C15H10N2O6 Molecular Weight: 314.25000

Description

A heterobifunctional coupling reagent useful for forming enzyme immunoconjugates. The reactive groups are the NHS ester and maeimide. Spacer Arm: 9.9 Angstroms

Basic Info

Chemical Name	3-Maleimidobenzoic acid N-hydroxysuccinimide ester
Synonyms	Succinimidylmaleimidobenzoate; Einecs 261-368-8; m-maleimimidobenzoyl-N-hydroxysuccinamide ester; 3-MaleiMidobenzoic acid-NHS ester; 3-maleimidobenzoyl N-hydroxysuccinimide ester; 3-N-Maleimidobenzoic acid-NHS; N-hydroxysuccimidyloxy m-maleimidobenzoate; m-maleimidobenzoyl-N-hydroxysuccinimide ester; N-SUCCINIMIDYL 3-MALEIMIDOBENZOATE; 3-Maleimido-benzoic acid-OSu; M-N-MALEIMIDOBENZOIC ACID-OSU; m-maleimidobenzoic acid succinimido ester; MBS;
CAS No.	58626-38-3
Molecular Formula	C15H10N2O6
Molecular Weight	314.25000
PSA	101.06000
LogP	0.33970

Properties

Appearance & Physical State	Crystalline
Density	1.59 g/cm3
Boiling Point	524.5ºC at 760 mmHg
Melting Point	175-177ºC(lit.)
Flash Point	271ºC
Refractive Index	1.678
Storage Condition	-20ºC

Safety Info

Safety Statements	26-36
WGK Germany	3
Risk Statements	R36/37/38
Hazard Codes	Xi
Symbol	GHS07
Hazard Declaration	H315; H319; H335
Signal Word	Warning
Caution Statement	P261; P305 + P351 + P338

Synthesis Route

(2,5-dioxopyrrolidin-1-yl) 2,2,2-trifluoroacetate+3-[[(2Z)-3-carboxy-1-oxo-2-propen-1-yl]amino]benzoic acid→3-Maleimidobenzoic acid N-hydroxysuccinimide ester
N-Hydroxysuccinimide+3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-benzoic acid→3-Maleimidobenzoic acid N-hydroxysuccinimide ester
N-Hydroxysuccinimide+3-[[(2Z)-3-carboxy-1-oxo-2-propen-1-yl]amino]benzoic acid→3-Maleimidobenzoic acid N-hydroxysuccinimide ester

Precursor

3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-benzoic acid
3-[[(2Z)-3-carboxy-1-oxo-2-propen-1-yl]amino]benzoic acid
N-Hydroxysuccinimide
(2,5-dioxopyrrolidin-1-yl) 2,2,2-trifluoroacetate

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