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2',2'-Difluoro-2'-deoxycytidine-3',5'-dibenzoate

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Origin: China

Cas No: 134790-39-9

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 134790-39-9 Formula: C23H19F2N3O6 Molecular Weight: 471.41000

Description

A (β-anomer) intermediate of Gemcitabine; antitumor compound.

Basic Info

Chemical Name	2',2'-Difluoro-2'-deoxycytidine-3',5'-dibenzoate
Synonyms	GeMcitabine InterMediate 9; 3',5'-Di-O-benzoyl-2'-deoxy-2',2'-difluorocytidine; 2'-deoxy-2,2'-difluoro-3,5-dibenzyl-cytidine; Chloropurine riboside;
CAS No.	134790-39-9
Molecular Formula	C23H19F2N3O6
Molecular Weight	471.41000
PSA	122.74000
LogP	3.02200

Properties

Appearance & Physical State	Tan Solid
Density	1.459 g/cm3
Boiling Point	608.383ºC at 760 mmHg
Flash Point	321.739ºC
Refractive Index	1.625
Vapor Pressure	0mmHg at 25°C

Safety Info

HS Code	2934999090

Synthesis Route

((2R,3R,5S)-3-(Benzoyloxy)-4,4-difluoro-5-((methylsulfonyl)oxy)tetrahydrofuran-2-yl)methyl benzoate+N-(Trimethylsilyl)-2-[(trimethylsilyl)oxy]pyrimidin-4-amine→1’-Epi Gemcitabine 3’,5’-Dibenzoate+2',2'-Difluoro-2'-deoxycytidine-3',5'-dibenzoate
2-deoxy-2,2-difluororibose→2',2'-Difluoro-2'-deoxycytidine-3',5'-dibenzoate
2-Deoxy-2,2-difluoro-D-erythro-pentonic Acid γ-Lactone 3,5-Dibenzoate→2',2'-Difluoro-2'-deoxycytidine-3',5'-dibenzoate

Precursor

((2R,3R,5S)-3-(Benzoyloxy)-4,4-difluoro-5-((methylsulfonyl)oxy)tetrahydrofuran-2-yl)methyl benzoate
N-(Trimethylsilyl)-2-[(trimethylsilyl)oxy]pyrimidin-4-amine
2-Deoxy-2,2-difluoro-D-erythro-pentonic Acid γ-Lactone 3,5-Dibenzoate
2-deoxy-2,2-difluororibose

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