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2-[6-[2-[4-[(2,4-dioxo-1,3-thiazolidin-5-yl)methyl]phenoxy]ethyl]pyridin-3-yl]acetic acid

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Origin: China

Cas No: 146062-48-8

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

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CAS No.: 146062-48-8 Formula: C19H18N2O5S Molecular Weight: 386.42200

Description

A metabolite of the antidiabetic Pioglitazone.

Basic Info

Chemical Name	2-[6-[2-[4-[(2,4-dioxo-1,3-thiazolidin-5-yl)methyl]phenoxy]ethyl]pyridin-3-yl]acetic acid
Synonyms	Pioglitazone Metabolite M5;
CAS No.	146062-48-8
Molecular Formula	C19H18N2O5S
Molecular Weight	386.42200
PSA	134.38000
LogP	2.50020

Synthesis Route

5-(4-(2-(5-cyanomethyl-2-pyridyl)ethoxy)benzyl)-2-imino-4-thiazolidinone→2-[6-[2-[4-[(2,4-dioxo-1,3-thiazolidin-5-yl)methyl]phenoxy]ethyl]pyridin-3-yl]acetic acid
(6-{2-[4-(2,4-Dioxo-thiazolidin-5-ylmethyl)-phenoxy]-ethyl}-pyridin-3-yl)-acetonitrile→2-[6-[2-[4-[(2,4-dioxo-1,3-thiazolidin-5-yl)methyl]phenoxy]ethyl]pyridin-3-yl]acetic acid
(6-methylpyridin-3-yl)methanol→2-[6-[2-[4-[(2,4-dioxo-1,3-thiazolidin-5-yl)methyl]phenoxy]ethyl]pyridin-3-yl]acetic acid

Precursor

5-(4-(2-(5-cyanomethyl-2-pyridyl)ethoxy)benzyl)-2-imino-4-thiazolidinone
Methyl 6-methylnicotinate
3-((methoxymethoxy)methyl)-6-methylpyridine
(6-methylpyridin-3-yl)methanol

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